Publications

Guan X, Okazaki Y, Lithio A, Li L, Zhao X, Jin H, Nettleton D, Saito K, Nikolau BJ. 2017. The 3-hydroxyacyl-ACP dehydratase component of the plant mitochondrial fatty acid synthase system. Plant Physiol 2017 Feb 15. pii: pp.01732.2016. doi: 10.1104/pp.16.01732. [Epub ahead of print]

Duenas ME, Klein AT, Alexander LE, Yandeau-Nelson MD, Nikolau BJ, Lee YJ. 2017. High spatial resolution mass spectrometry imaging reveals the genetically programmed, developmental modification of the distribution of thylakoid membrane lipids among individual cells of maize leaf. Plant J. 89(4):825-838. doi: 10.1111/tpj.13422. Epub 2017 Feb 3.

Rizhsky L, Jin H, Shepard MR, Scott HW, Teitgen AM, Perera MA, Mhaske V, Jose A, Zheng X, Crispin M, Wurtele ES, Jones D, Hur M, Góngora-Castillo E, Buell CR, Minto RE, Nikolau BJ. 2016. Integrating metabolomics and transcriptomics data to discover a biocatalyst that can generate the amine precursors for alkamide biosynthesis. Plant J 88(5):775-793. doi: 10.1111/tpj.13295. Epub 2016 Sep 27.

Guan X, Nikolau BJ. 2016. AAE13 encodes a dual-localized malonyl-CoA synthetase that is crucial for mitochondrial fatty acid biosynthesis. Plant J. 85(5):581-93. doi: 10.1111/tpj.13130. PMID: 26836315. Featured article on the cover of the April 2016 issue.

Garg S, Rizhsky L, Jin H, Yu X, Jing F, Yandeau-Nelson MD, Nikolau BJ. 2016. Microbial production of bi-functional molecules by diversification of the fatty acid pathway. Metab Eng. Jan 28. doi: 10.1016/j.ymben.2016.01.003. PMID26827988.

Wessen LB, Bender RL, Paradis T, Larson A, Perera MA, Nikolau BJ, Olszewski NE, Carter CJ. 2015. A role for GIBBERELLIN 2-OXIDASE6 and gibberellins in regulating nectar production. Mol Plant 9(5):753-6. doi: 10.1016/j.molp.2015.12.019. Epub 2015 Dec 31.PMID 26748313.

Guan X, Chen H, Abramson A, Man H, Wu J, Yu O, Nikolau BJ. 2015. A phosphopantetheinyl transferase that is essential for mitochondrial fatty acid biosynthesis. Plant J. Sep 24. doi. 10.1111/tpj.13034.

Li L, Zheng W, Zhu Y, Ye H, Tang B, Arendsee ZW, Jones D, Li R, Ortiz D, Zhao X, Du C, Nettleton D, Scott MP, Salas-Fernandez MG, Yin Y, Wurtele ES. 2015. QQS orphan gene regulates carbon and nitrogen partitioning across species via NF-YC interactions. PNAS, 112(47):14734-9. doi: 10.1073/pnas.1514670112. Epub 2015 Nov 9.

Noutsos C, Perera AM, Nikolau BJ, Seaver SM, Ware DH. 2015. Metabolomic profiling of the nectars of Aquilegia pubescens and A. canadensis. PLoS One, 10:e0124501. doi:10.137/journal.pone.0124501. PMID: 25933103.

Smelser A, Blanco M, Lübberstedt T, Gardner C, Schechert A, Vanous A, de la Fuente G. 2015. Weighing in on a method to discriminate maize haploid from hybrid seed. Plant Breeding 134: 283-285. doi: 10.1111/pbr.12260.

Li L, Hur M, Lee JY, Zhou W, Song Z, Ransom N, Demirkale CY, Nettleton D, Westgate M, Arendsee Z, Iyer V, Shanks J, Nikolau B, Wurtele ES. 2015. A systems biology approach toward understanding seed composition in soybean. BMC Genomics, Suppl 3:S9. doi: 10.1186/1471-2164-16-S3-S9. PMID:25708381.

Kim T, Dreher K, Nilo-Poyanco R, Lee I, Fiehn O, Lange BM, Nikolau BJ, Sumner L, Welti R, Wurtele ES, Rhee SY. 2015. Patterns of metabolite changes identified from large-scale perturbations in Arabdopsis using a genome-scale metabolic network. Plant Physiol 167:1685-1698. doi: 10.1104/pp.114.252361. PMID 25670818.

Korte AR, Yandeau-Nelson MD, Nikolau BJ, Lee YJ. 2015. Subcellular-level resolution MALDI-MS imaging of maize leaf metabolites my MALDI-linear ion trap-Orbitrap mass spectrometer. Anal Bioanal Chem, 407(8):2301-9. doi: 10.1007/s00216-015-8460-5. Epub 2015 Jan 25.. PMID: 25618761.

Sumner LW, Lei Z, Nikolau BJ, Saito K. 2015. Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects. Nat Prod Rep 32:212-229. doi: 10.1039/c4np00072b.

Jin H, Nikolau BJ. 2014. Evaluating PHA productivity of bioengineered Rhodosprillum rubrum. PLoS One 9:e96621. doe: 10.1371/journal.pone.0096621.

Fukushima A, Kusano M, Mejia RF, Iwasa M, Kobayashi M, Hayashi N, Watanabe-Takahashi A, Narisawa T, Tohg T, Hur M, Wurtele ES, Nikolau BJ, Saito K. 2014. Metabolomic characterization of knock-out mutants in Arabidopsis - Development of a metabolite profiling database for knock-out mutants in Arabidopsis (MeKO). Plant Physiology May 2014 pp.114.240986. doi:10.1104/pp.114.240986

Hur M, Campbell AA, Almeida-de-Macedo M, Li L, Ransom N, Jose A, Crispin M, Nikolau BJ, Wurtele ES. 2013. A global approach to analysis and interpretation of metabolic data for plant natural product discovery. Nat Prod Rep. 30(4):565-83. doi: 10.1039/c3np20111b. PMID: 23447050.

Jones R, Reinot T, Frei UK, Tseng Y, Lübberstedt T, McClelland J. 2012. Selection of haploid maize kernels from hybrid kernels for planbBreeding using near infrared spectroscopy and SIMCA analysis. Applied Spectroscopy 66: 110-119. doi: 10.1366/11-06426.

Jin H, Nikolau BJ. 2012. The role of genetic redundancy in polyhydroxyalkanoate (PHA) polymerases in PHA biosynthesis in Rhodospirillum rubrum. J. Bacteriology. 194(20):5522-9. Epub 2012 Aug 3. PMID: 22865850.

Muhlemann J, Maeda H, Chang CY, San Miguel P, Baxter I, Cooper B, Perera MA, Nikolau BJ, Vitek O, Morgan JA, Dudareva N. 2012. Developmental changes in the metabolic network of snapdragon flowers. PLoS ONE 7(7):e40381. doi: 10.1371/journal.pone.0040381. Epub 2012 Jul 11. PMID: 22808147.

Quanbeck, SM, Brachova L, Campbell AA, Guan X, Perera  A, He K, Rhee SY, Bais P, Dickerson JA, Dixon P, Wohlgemuth G, Fiehn O, Barkan L, Lange I, Lange BM, Lee I, Cortes D, Salazar C, Shuman J, Shulaev V, HuhmanDV, Sumner LW, Roth MR, Welti R, Ilarslan H, Wurtele ES and Nikolau BJ. 2012. Metabolomics as a hypothesis-generating functional genomics tool for the annotation of Arabidopsis thaliana genes of "unknown function." Frontiers in Plant Science 3:15. doi: 10.3389/fpls.2012.00015. eCollection 2012. PMID: 22645570.

Lee Y J; Perdian D C; Song Z H; Yeung E S; Nikolau B J . 2012. Use of mass spectrometry for imaging metabolites in plants. Plant Journal 70(1):81-95. doi: 10.1111/j.1365-313X.2012.04899.x. PMID: 22449044.

Wurtele, ES, Cappell, J, Jones, AD, Celiz, MD, Ransom, N, Hur, M, Rizshsky, L, Crispin, M, Dixon, P, Liu, J, Widrlechner, MP, and Nikolau, BJ. 2012. Medicinal plants: A public resource for metabolomics and hypothesis development. Metabolites 2(4): 1031-1059. doi:10.3390/metabo2041031.

Jin H, Song Z, Nikolau BJ. 2012. Reverse genetic characterization of two paralogous acetoacetyl CoA thiolase genes in Arabidopsis reveals their importance in plant growth and development. Plant J. 70(6):1015-32. doi: 10.1111/j.1365-313X.2012.04942.x. Epub 2012 Mar 31. PMID: 22332816.

Ding G, Che P, Ilarslan H, Syrkin Wurtle E, Nikolau BJ. 2011. Genetic dissection of methylcrotonyl-CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. Plant Journal 70(4):562-77. doi: 10.1111/j.1365-313X.2011.04893.x. Epub 2012 Feb 6. PMID: 22211474.

Jones R, Reinot T, Frei UK, Tseng Y, Lübberstedt T, McClelland J. 2012. Selection of haploid maize kernels from hybrid kernels for plant breeding using near infrared spectroscopy and SIMCA analysis. Applied Spectroscopy 66: 110-119. doi: 10.1366/11-06426.

Korte A R, Song ZH, Nikolau BJ, Lee YJ. 2012. Mass spectrometric imaging as a high-spatial resolution tool for functional genomics: Tissue-specific gene expression of TT7 inferred from heterogeneous distribution of metabolites in Arabidopsis flowers. Analytical Methods 4:474-481. doi: 10.1039/C2AY05618F.

Bais P, Moon-Quanbeck S, Nikolau BJ, Dickerson JA. 2011. Plant metabolomics.org: mass spectrometry-based Arabidopsis metabolomics - database and tools update. Nucleic Acids Research 40(Database issue):D1216-20. doi: 10.1093/nar/gkr969. Epub 2011 Nov 10. PMID: 22080512.

Jing F, Cantu DC, Tvaruzkova J, Chipman JP, Nikolau BJ, Yandeau-Nelson MD, Reilly PJ. 2011. Phylogenetic and experimental characterization of an acyl ACP thioesterase family reveals significant diversity in enzymatic specificity and activity. BMC Biochem 12:44. doi: 10.1186/1471-2091-12-44. PMID: 21831316.

Chen Y, Apolinario E, Brachova L, Kelman Z, Li Z, Nikolau BJ, Showman L, Sowers K, Orban J. 2011. A nuclear magnetic resonance based approach to accurate functional annotation of putative enzymes in the methanogen Methanosarcina acetivorans. BMC Genomics 12 Suppl 1:S7. doi: 10.1186/1471-2164-12-S1-S7. PMID: 21810209.

Schmidt MA, Barbazuk B, Sandford M, May G, Song Z, Zhou W, Nikolau BJ, Herman EM. 2011. Silencing of soybean seed storage proteins results in a rebalanced protein composition preserving seed protein content without major collateral changes in the metabolome and transcriptome. Plant Physiology 156(1):330-45. doi: 10.1104/pp.111.173807. Epub 2011 Mar 10. PMID: 21398260.

Perera MADN, Qin W, Yandau-Nelson M, Fan L, Dixon P, Nikolau BJ. 2010. Biological origins of normal-chain hydrocarbons. Plant Journal 64(4):618-32. doi: 10.1111/j.1365-313X.2010.04355.x. Epub 2010 Oct 26. PMID: 21070415.

Li X, Ilarslan H, Brachova L, Qian HR, Li L, Che P, Wurtele ES, Nikolau BJ.  2011. Reverse genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-CoA carboxylase indicates a unidirectional functional redundancy. Plant Physiology 155:293-314. doi: 10.1104/pp.110.165910. Epub 2010 Oct 28. PMID: 21030508.

Jiang Y, Nikolau BJ, Ma Y. 2010. Separation and quantification of short-chain coenzyme A in plant tissues by capillary electrophoresis with laser-induced fluorescence detection. Analytical Methods 2:1900-1904. doi: 10.1039/C0AY00425A.

Jun JH, Song Z, Liu Z, Nikolau BJ, Yeung ES, Lee YJ.  2010. High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver. Analytical Chemistry 82(8):3255-65. doi: 10.1021/ac902990p. PMID: 20235569.

Bais P, Moon SM, He K, Leitao R, Dreher K, Walk T, Sucaet Y, Barkan L, Wohlgemuth G, Roth MR, Wurtele ES, Dixon P, Fiehn O, Lange BM, Shulaev V, Sumner LW, Welti R, Nikolau BJ, Rhee SY, Dickerson JA.  2010.  PlantMetabolomics.org: a web portal for plant metabolomics experiments. Plant Physiology 152(4):1807-16. doi: 10.1104/pp.109.151027. Epub 2010 Feb 10. PMID: 20147492.

Oliver DJ, Nikolau BJ, Wurtele ES.  2009. Acetyl-CoA—Life at the metabolic nexus. Plant Science 176: 597-601. http://dx.doi.org/10.1016/j.plantsci.2009.02.005

Cha S, Song Z, Nikolau BJ and Yeung ES. 2009. Direct profiling and imaging of epicuticular waxes on Arabidopsis thaliana by laser desorption/ionization mass spectrometry using silver colloid as a matrix. Analytical Chemistry 81(8):2991-3000. doi: 10.1021/ac802615r. PMID: 19290666.

Perera MA, Choi SY, Wurtele ES and Nikolau BJ. 2009. Quantitative analysis of short-chain acyl-coenzymeAs in plant tissues by LC-MS-MS electrospray ionization method. J Chromatography B Analytical Technology Biomedical Life Science 877(5-6):482-8. doi: 10.1016/j.jchromb.2008.12.053. Epub 2008 Dec 30. PMID: 19157998.

Mentzen WI, Peng J, Ransom N, Nikolau BJ, Wurtele ES. 2008. Articulation of three core metabolic processes in Arabidopsis: fatty acid biosynthesis, leucine catabolism and starch metabolism. BMC Plant Biology 8:76. doi: 10.1186/1471-2229-8-76. PMID: 18616834.

Nikolau BJ, Perera MA, Brachova L, Shanks B. 2008. Platform biochemicals for a biorenewable chemical industry. Plant Journal 54(4):536-45. doi: 10.1111/j.1365-313X.2008.03484.x. PMID: 18476861.

Aguilar JA, Diaz-Perez C, Diaz-Perez AL, Rodriguez-Zavala JS, Nikolau BJ, Campos-Garcia J. 2008. Substrate specificity of the 3-methylcrotonyl coenzyme A (CoA) and geranyl-CoA carboxylases from Pseudomonas aeruginosa. Journal Bacteriology 190(14):4888-93. doi: 10.1128/JB.00454-08. Epub 2008 May 9. PMID: 18469096.

Cha S, Zhang H, Ilarslan HI, Wurtele ES, Brachova L, Nikolau, BJ, Yeung, ES. 2008. Direct profiling and imaging of plant metabolites in intact tissues by using colloidal graphite-assisted laser desorption ionization mass spectrometry. Plant Journal 55(2):348-60. doi: 10.1111/j.1365-313X.2008.03507.x. Epub 2008 Apr 4. PMID: 18397372.

Fiehn O, Wohlgemuth G, Scholz M, Kind T, Lee do Y, Lu, Y., Moon, S., Nikolau, BJ. 2008. Quality control for plant metabolomics: reporting MSI-compliant studies. Plant Journal 53(4):691-704. doi: 10.1111/j.1365-313X.2007.03387.x. PMID: 18269577.

Muralla R, Chen E, Sweeney C, Gray JA, Dickerman A, Nikolau, B.J., Meinke, D. 2008. A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis. Plant Physiology 146(1):60-73. Epub 2007 Nov 9. doi: 10.1104/pp.107.107409. PMID: 17993549.

Dietrich CR, Perera MADN, Yandeau M, Meeley RB, Nikolau BJ, Schnable PS. 2005. Characterization of two GL8 paralogs reveals that the 3-ketoacyl reductase component of fatty acid elongase is essential for maize (Zea mays L.) development. Plant Journal 42(6):844-61. doi: 10.1111/j.1365-313X.2005.02418.x. PMID: 15941398.

Sluszny C, Yeung ES, Nikolau BJ. 2005. In situ probing of the biotic-abiotic boundary of plants by laser desorption/ionization time-of-flight mass spectrometry. Journal of the American Society of Mass Spectrometry. 16(1):107-15. doi: 10.1016/j.jasms.2004.09.023. PMID: 15653370.

Fatland BL, Nikolau BJ, Wurtele ES. 2005. Reverse genetic characterization of cytosolic acetyl-CoA generation by ATP-citrate lyase in Arabidopsis. Plant Cell 17(1):182-203. Epub 2004 Dec 17. doi: 10.1105/tpc.104.026211. PMID: 15608338.

Bino RJ, Hall RD, Fiehn O, Kopka J, Saito K, Draper J, Nikolau BJ, Mendes P, Roessner-Tunali U, Beale MH, Trethewey RN, Lange BM, Wurtele ES, Sumner LW. 2004. Potential of metabolomics as a functional genomics tool. Trends Plant Sci 9:418-425. doi: 10.1016/j.tplants.2004.07.004. PMID: 15337491.

Che P, Weaver LM, Wurtele ES, Nikolau BJ. 2003. The role of biotin in regulating 3-methylcrotonyl-CoA carboxylase expression in Arabidopsis. Plant Physiology 131(3):1479-86. doi: 10.1104/pp.013243. PMID: 12644697.

Fatland BL, Ke J, Anderson M, Mentzen W, Cui LW, Allred C, Johnston JL, Nikolau BJ, Wurtele ES. 2002. Molecular characterization of a novel heteromeric ATP-citrate lyase that generates cytosolic pool of acetyl-CoA in Arabidopsis. Plant Physiology 130(2):740-56. doi: 10.1104/pp.008110. PMID: 12376641.

Che P, Wurtele ES, Nikolau BJ. 2002. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. Plant Physiology 129(2):625-37. doi: 10.1104/pp.001842. PMID: 12068107.

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